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Ferroptosis in Ischemic Stroke Cellular Metabolic Mechanism of Ferroptosis Ferroptosis can be initiated through two major pathways: the extrinsic, or transporter-dependent pathway, and the intrinsic, or enzyme regulated pathway

Cancer Immunol Immunother 33(5):327-32, 1991

Most promisingly, we could successfully soak in and solve crystal structures with the NMR hit 27 and several of its analogues to fully characterise the binding modes within this fragment hit series